Konstantinos Maltezos studied in the University of Athens and continued his studies, also with a scholarship, in Physics, in Sorbonne, in the Collège de France and in the Ecole Polytechnique. After his return to Greece, he taught in the Greek Military School, in the University of Athens and the Polytechnic School. He became a member of the Academy of Athens and of numerous other scientfic organizations. He published many books and articles on a variety of subjects, such as elasticity and astronomy.

One of the first students and graduates of the Greek Military Academy in 1831. He joined the artillery Corps, in which he served for forty four years, attaing the rank of Major General. He also studied abroad and taught Higher Mathematics and Fortifications in the Greek Military Academy.